|
KMID : 1161420110140030195
|
|
Journal of Medicinal Food
2011 Volume.14 No. 3 p.195 ~ p.200
|
|
|
Zizyphus Enhances Cell Proliferation and Neuroblast Differentiation in the Subgranular Zone of the Dentate Gyrus in Middle-Aged Mice
|
|
Hwang In-Koo
Yoo Ki-Yeon
Yoo Dae-Young
Choi Jung-Hoon
Lee Choong-Hyun
Kang Il-Jun
Kwon Dae-Young
Kim Young-Sup
Kim Dong-Woo
Won Moo-Ho
|
|
|
Abstract
|
|
|
|
Zizyphus jujuba is considered to have various physiological functions in the brain. We obtained a Z. jujuba methanol extract (ZJE) and observed its effects on neurogenesis in middle-aged mice. Twelve-month-old mice received repeated oral administrations of ZJE for 30 days. The administration of ZJE significantly increased the number of Ki67 (a marker for cell proliferation)-positive cells in the subgranular zone of the dentate gyrus of middle-aged mice. Furthermore, ZJE significantly increased doublecortin (a marker for neuroblast differentiation)-immunoreactive neuroblasts with tertiary dendrites, but not those without tertiary dendrites, in the dentate gyrus. In addition, doublecortin protein levels in the ZJE-treated groups tended to increase dose-dependently. These results suggest that the repeated supplement of ZJE may increase the hippocampal plasticity in middle-aged mice.
|
|
|
KEYWORD
|
|
|
dentate gyrus, doublecortin, Ki67, neurogenesis, Zizyphus jujuba
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|